Publications

Key Publications

2024

Leow, Y. J., Soo, S. A., Kumar, D., Zailan, F. Z. B., Sandhu, G. K., Vipin, A., … & Kandiah, N. (2024). Mild Behavioral Impairment and Cerebrovascular Profiles Are Associated with Early Cognitive Impairment in a Community-Based Southeast Asian Cohort. Journal of Alzheimer’s Disease, (Preprint), 1-9.

Leow, Y. J., Wang, J. D. J., Vipin, A., Sandhu, G. K., Soo, S. A., Kumar, D., … & Kandiah, N. (2024). Biomarkers and Cognition Study, Singapore (BIOCIS): Protocol, Study Design, and Preliminary Findings. The Journal of Prevention of Alzheimer’s Disease, 1-13.

Vipin, A., Lee, B. T. K., Kumar, D., Soo, S. A., Leow, Y. J., Ghildiyal, S., Lee, F. P. H. E., Hilal, S., & Kandiah, N. (2024). The role of perfusion, grey matter volume and behavioural phenotypes in the data-driven classification of cognitive syndromes. Alzheimer’s Research & Therapy, 16(1), 40.

Leow, Y. J., Dang, C., & Kandiah, N. (2024). Analysis of the effectiveness of structured cognitive rehabilitation therapy in post-stroke cognitive impairment patients in Singapore. Chinese Journal of Nervous and Mental Diseases, 50(4).

Fandler-Höfler, S., Eppinger, S., Ambler, G., Nash, P., Kneihsl, M., Lee, K. J., … & Gattringer, T. (2024). Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds. JAMA network open, 7(10), e2439571-e2439571.

Rykov, Y. G., Patterson, M. D., Gangwar, B. A., Jabar, S. B., Leonardo, J., Ng, K. P., & Kandiah, N. (2024). Predicting cognitive scores from wearable-based digital physiological features using machine learning: data from a clinical trial in mild cognitive impairment. BMC medicine, 22(1), 36.

Nicholas, E., Lim, K., Yeo, B. S. Y., Lee, R. S., Lim, J. X., Chan, Y. H., … & Merchant, R. A. (2024). Motoric Cognitive Risk Syndrome As A Predictive Factor of Cognitive Impairment and Dementia–A Systematic Review and Meta-Analysis. Ageing Research Reviews, 102470.

Rykov, Y. G., Ng, K. P., Patterson, M. D., Gangwar, B. A., & Kandiah, N. (2024). Predicting the severity of mood and neuropsychiatric symptoms from digital biomarkers using wearable physiological data and deep learning. Computers in Biology and Medicine, 180, 108959.

Tan, W. Y., Hargreaves, C. A., Dawe, G. S., Hsu, W., Lee, M. L., Vipin, A., … & Hilal, S. (2024). Incremental value of multidomain risk factors for dementia prediction: a machine learning approach. The American Journal of Geriatric Psychiatry.

Prats-Sanchez, L., Camps-Renom, P., Nash, P. S., Wilson, D., Ambler, G., Best, J. G., … & Microbleeds International Collaborative Network (MICON). (2024). Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds. Neurology, 102(7), e209173.

Lee, J. H., Jia, J., Ji, Y., Kandiah, N., Kim, S., Mok, V., … & Chen, C. (2024). A Framework for Best Practices and Readiness in the Advent of Anti-Amyloid Therapy for Early Alzheimer’s Disease in Asia. Journal of Alzheimer’s Disease, 101(1), 1-12.

2023

Koh, W, Soo SA, Saffari SE, Chiew HJ, Ng ASL, Ng KP, Kandiah N. Normative data for baseline and longitudinal neuropsychological assessments in Singapore. Accepted for publication in Annals Academy of Medicine, Singapore in Oct 2023.

Vipin A, Kumar D, Soo SA, Zailan FZ, Leow YJ, Koh CL, Ng ASL, Ng KP, Kandiah N. APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia. Alzheimer’s Research & Therapy, 15 (1), 103. DOI:10.1186/s13195-023-01251-4

Soo SA, Kumar D, Leow YJ, Koh CL, Saffari SE and Kandiah N. Usefulness of the Visual Cognitive Assessment Test (VCAT) in detecting mild cognitive impairment in the community. April 2023, Journal of Alzheimer’s Disease, 93 (2), 755-763. DOI:10.3233/JAD-221301

Tan J, Wee ACW, Foo JN, Lian MM, Lim WK, Dominguez JC, Fong ZH, Narasimhalu K, Chiew HJ, Ng KP, Ting SKS, Kandiah N, Ng A. C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort. February 2023. Annals of Clinical and Translational Neurology, 17, PMID: 36799407, DOI: 10.1002/acn3.51744

Tan J, Siow I, Saffari SE, Ting SKS, Zeng L, Kandiah N, Tan LCS, Tan EK, Ng A. Plasma Soluble ST2 Levels Are Higher in Neurodegenerative Disorders and Associated with Poorer Cognition. February 2023. Journal Of Alzheimer’s Disease, 92 (2), 1-8, PMID: 36776067, DOI: 10.3233/JAD-221072

2022

Kumar S, Luca AD, Leemans A, Saffari SE, Hartono S, Zailan FZ, Ng KP, Kandiah N. Topology of diffusion changes in corpus callosum in Alzheimer’s disease: An exploratory case-control study. Frontiers of Neurology, November 2022, 13, PMID: 36530616, DOI: 10.3389/fneur.2022.1005406

Yeap YJ, Kandiah N, Nizetic D, Lim KH. BACE2: A Promising Neuroprotective Candidate for Alzheimer’s Disease. November 2022, Journal Of Alzheimer’s Disease, PMID: 36463454, DOI: 10.3233/JAD-220867

Kandiah N, Choi SH, Hu CJ, Ishii K, Kasuga K, Mok VCT. Current and Future Trends in Biomarkers for the early detection of Alzheimer’s Disease in Asia: Expert Opinion, Journal of Alzheimer’s Disease Reports, November 2022, 6(1), 699-710. PMID: 36606209, DOI: 10.3233/ADR-220059

Vipin A, Koh CL, Wong BYX, Zailan FZ, Tan JY, Soo SA, Satish V, Kumar D, Wang BZ, Ng A, Chiew HJ, Ng KP, Kandiah N. Amyloid tau neurodegeneration profiles and longitudinal cognition in sporadic young onset dementia, Journal of Alzheimer’s Disease, September 2022, 90 (2), 543-551. PMID: 36155511, DOI:10.3233/JAD-220448

Oh SL, Zhou MK, Chin, EWM, Amarnath, G, Cheah, CH, … Kandiah, N… Chiam, KH. Alzheimer’s Disease Blood Biomarkers Associated With Neuroinflammation as Therapeutic Targets for Early Personalized Intervention. 11 July 2022, Frontiers in Digital Health, 4 (875895). PMID: 35899035, DOI:10.3389/fdgth.2022.875895

Sandhu GK, Zailan FZ, Vipin A, Soo SA, Kumar D, Ng KP, Kandiah N. Correlation between plasma Oligomeric Amyloid Beta and performance on the language neutral Visual Cognitive Assessment Test in a Southeast Asian population. Journal of Alzheimer’s Disease. 2022 Jul 11.PMID: 35848029, DOI:10.3233/JAD-220484

Chia SY, Vipin A, Ng KP, Tu H, Bommakanti A, Wang BZ, Tan YJ, Zailan FZ, Ng AS, Ling SC, Okamura K, Tan EK, Kandiah N, Zeng L. Upregulated Blood miR-150-5p in Alzheimer’s Disease Dementia Is Associated with Cognition, Cerebrospinal Fluid Amyloid-β, and Cerebral Atrophy. J Alzheimers Dis. 2022 Jul 5. PMID: 35811521 doi:10.3233/JAD-220116

Kumar, D, Yatawara, C, Wang, BZ, Wong, B, Tan, Y.J, Zailan, FZ, Ng, KP, Kandiah, N. APOE E4 and confluent WMH have a synergistic effect on episodic memory impairment in prodromal dementia. 2022. Journal of Alzheimer’s Disease, 87 (3), 1-12. PMID: 35431245, DOI:10.3233/JAD-215556

X Xu, KA Chew, ZX Wong, AKS Phua… N Kandiah, CL-H Chen. The Singapore Geriatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol. (2022). The Journal of prevention of Alzheimer’s Disease, 9(1), 40-48. PMID: 35098972, DOI: 10.14283/jpad.2022.5

Soo SA, Zailan FZ, Tan JY, Sandhu GK, Wong BYX, Wang BZ, Ng ASL, Chiew HJ, Ng KP, Kandiah N. Safety and Usefulness of Lumbar Puncture for the Diagnosis and Management of Young-Onset Cognitive Disorders. 2022. Journal of Alzheimer’s Disease, 87 (Suppl 1), 1-10. PMID: 35275537, DOI:10.3233/JAD-215453

2021

Vipin A, Satish V, Saffari SE, Koh W, Lim L, Silva E, Nyu MM, Choong TM, Chua E, Lim L, Ng ASL, Chiew HJ, Ng KP, Kandiah N. Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease. Alzheimers Res Ther. 2021 Nov 30;13(1):195. doi: 10.1186/s13195-021-00936-y. PMID: 34847922; PMCID: PMC8630908.

Wong FCC, Saffari SE, Yatawara C, Ng KP, Kandiah N; Alzheimer’s Disease Neuroimaging Initiative. Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals. J Alzheimers Dis. 2021;84(1):91-101. doi: 10.3233/JAD-210333. PMID: 34511497.

Ng KP, Cheng GH, Yatawara C, Rosa-Neto P, Gauthier S, Kandiah N; Alzheimer’s Disease Neuroimaging Initiative. Baseline Neurodegeneration Influences the Longitudinal Effects of Tau on Cognition. J Alzheimers Dis. 2021;82(1):159-167. doi: 10.3233/JAD-201425. PMID: 33998536.

Soo SA, Ng KP, Wong F, Saffari SE, Yatawara C, Ismail Z, Kandiah N. The Association Between Diabetes Mellitus and Mild Behavioral Impairment Among Mild Cognitive Impairment: Findings from Singapore. J Alzheimers Dis. 2021;82(1):411-420. doi: 10.3233/JAD-210037. PMID: 34024829.

Vipin A, Wong BYX, Kumar D, Low A, Ng KP, Kandiah N. Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional. Aging (Albany NY). 2021 Apr 16;13(8):10973-10988. doi: 10.18632/aging.202977. Epub 2021 Apr 16. PMID: 33861727; PMCID: PMC8109133.

Ng KP, Chiew HJ, Hameed S, Ting SKS, Ng A, Soo SA, Wong BYX, Lim L, Yong ACW, Mok VCT, Rosa-Neto P, Dominguez J, Kim S, Hsiung GYR, Ikeda M, Miller BL, Gauthier S, Kandiah N. Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research. Alzheimers Dement (N Y). 2021 Jan 15;6(1):e12085. doi: 10.1002/trc2.12085. PMID: 33490361; PMCID: PMC7810128.

Kandiah N, Chan YF, Chen C, Dasig D, Dominguez J, Han SH, Jia J, Kim S, Limpawattana P, Ng LL, Nguyen DT, Ong PA, Raya-Ampil E, Saedon N, Senanarong V, Setiati S, Singh H, Suthisisang C, Trang TM, Turana Y, Venketasubramanian N, Yong FM, Youn YC, Ihl R. Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS Neurosci Ther. 2021 Feb;27(2):149-162. doi: 10.1111/cns.13536. Epub 2020 Dec 22. PMID: 33352000; PMCID: PMC7816207.

2020

Kumar D, Vipin A, Wong B, Ng KP, Kandiah N. Differential Effects of Confluent and Nonconfluent White Matter Hyperintensities on Functional Connectivity in Mild Cognitive Impairment. Brain Connect. 2020 Dec;10(10):547-554. doi: 10.1089/brain.2020.0784. Epub 2020 Nov 16. PMID: 33050714.

Koh, W., Lim, L., Low, A., Wong, B., Lim, L., Silva, E., …Kandiah, N. Development and validation of a brief visual based cognitive screening tool for dementia: the Visual Cognitive Assessment Test short-form (VCAT-S). Journal of Neurology, Neurosurgery, and Psychiatry. 91 (10), 1122-1123. DOI: 10.1136/jnnp-2020-323106. PMID:32732390.

Wong FCC, Yatawara C, Low A, Foo H, Wong BYX, Lim L, Wang B, Kumar D, Ng KP, Kandiah N. Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment. Transl Stroke Res. 2021 Apr;12(2):284-292. doi: 10.1007/s12975-020-00847-4. Epub 2020 Sep 7. PMID: 32894401.

Wang BZ, Zailan FZ, Wong BYX, Ng KP, Kandiah N. Identification of novel candidate autoantibodies in Alzheimer’s disease. Eur J Neurol. 2020 Nov;27(11):2292-2296. doi: 10.1111/ene.14290. Epub 2020 May 25. PMID: 32356904.

Low, A., Lim, L., Lim, L., Wong, B., Silva, E., …Kandiah, N. Construct validity of the Visual Cognitive Assessment Test (VCAT) – A cross-cultural language-neutral cognitive screening tool. International psychogeriatrics. 32 (1), 141-149. DOI: 10.1017/S1041610219000504. PMID: 31111797.

2019

Low, A., Ng K.P., Chander, R.J., Wong, B., Kandiah, N. Association of Asymmetrical White Matter Hyperintensities and Apolipoprotein E4 on Cognitive Impairment. Journal of Alzheimer’s Disease, 70 (3), 1-12. DOI: 10.3233/JAD-190159. PMID: 31306121.

Low, A., Foo, H., Yong, T.T. Tan, L.C.S., Kandiah, N. Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson’s disease. Journal of Neurology, Neurosurgery and psychiatry, 90 (6), 681-687. DOI: 10.1136/jnnp-2018-319592. PMID: 30683708.

2018

Yatawara C, Ng KP, Chander R, Kandiah N. Associations between lesions and domain-specific cognitive decline in poststroke dementia. Neurology. 2018 Jul 3;91(1):e45-e54. doi: 10.1212/WNL.0000000000005734. Epub 2018 May 25. PMID: 29802171.

Ng, A., Tan, Y.J., Yi, Z., Tandiono, M., Chew E.,… Kandiah, N. Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement. Neurobiology of Aging 68 (160).. E15-160.E19. DOI: 10.1016/j.neurobiolaging.2018.04.003. PMID:29748150.

2017

Lim, L., Zhang, A., Lim, L., Choong, T., Silva, E.,… Kandiah, N. High Caregiver Burden in Young Onset Dementia: What Factors Need Attention? Journal of Alzheimer’s Disease. 61 (2), 537-543. DOI: 10.3233/JAD-170409. PMID: 29171995.

2016

Kandiah N, Zhang A, Bautista DC, Silva E, Ting SK, Ng A, Assam P. Early detection of dementia in multilingual populations: Visual Cognitive Assessment Test (VCAT). J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):156-60. DOI: 10.1136/jnnp-2014-309647. Epub 2015 Feb 17. PMID: 25691617.

Yatawara, C., Lim, L., Chander, R., Zhou, J., Kandiah, N. Depressive symptoms influence global cognitive impairment indirectly by reducing memory and executive function in patients with mild cognitive impairment. Journal of Neurology Neuosurgery and Psychiatry, 87 (12), 1375-1383. DOI: 10.1136/jnnp-2016-314191. PMID: 28103200.